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Induction of Experimental Autoimmune Hypophysitis in SJL Mice
Published on: December 17, 2010
Lymphocytic hypophysitis accompanied by aseptic meningitis mimics subacute meningoencephalitis
Keisuke Suzuki1, Naoki Izawa, Toshiki Nakamura
1Department of Neurology, Dokkyo Medical University, Japan. keisuke@dokkyomed.ac.jp
Abstract:
A 66-year-old man was admitted to our hospital with muscle pain, fatigue and appetite loss that had lasted for a month. The patient was somnolent and had nuchal stiffness with a high fever. Cerebrospinal fluid (CSF) tests demonstrated lymphocytic pleocytosis with a decreased CSF-blood glucose ratio. The tests for tuberculous, fungal and carcinomatous meningitis and herpetic meningoencephalitis were negative. Endocrinological exams showed hypopituitarism and diabetes insipidus. A pituitary MRI showed an enlargement of the pituitary stalk. A diagnosis of lymphocytic hypophysitis with aseptic meningitis was made after the exclusion of secondary hypophysitis. Lymphocytic hypophysitis with aseptic meningitis can mimic subacute meningoencephalitis.
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