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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.

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Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection
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Published on: June 23, 2023

Mobilisation strategies for normal and malignant cells.

L Bik To1, Jean-Pierre Levesque, Kirsten E Herbert

  • 1Haematology, IMVS/SA Pathology and Royal Adelaide Hospital, Adelaide, Western Australia, Australia. bik.to@health.sa.gov.au

Pathology
|September 17, 2011
PubMed
Summary

This review covers best practices for mobilizing hematopoietic stem cells for transplantation. It explores how understanding the stem cell niche optimizes mobilization and discusses the clinical implications of mobilizing other cell types.

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Area of Science:

  • Hematology
  • Stem Cell Biology
  • Transplantation Medicine

Background:

  • Hematopoietic stem cell transplantation (HSCT) relies on effective stem cell mobilization.
  • Optimizing mobilization is crucial for successful transplantation outcomes.
  • The bone marrow stem cell niche influences mobilization strategies.

Purpose of the Study:

  • To review current best practices for hematopoietic stem cell mobilization.
  • To explore how stem cell niche insights can optimize mobilization regimens.
  • To examine the mobilization of mesenchymal stromal cells, immune cells, and malignant cells and their clinical implications.

Main Methods:

  • Literature review of recent advancements in stem cell mobilization.
  • Analysis of the role of the bone marrow microenvironment in stem cell release.
  • Evaluation of clinical data on various cell mobilization strategies.

Main Results:

  • Current best practices for hematopoietic stem cell mobilization are detailed.
  • New insights into the stem cell niche offer strategies for optimizing mobilization.
  • The review discusses the clinical relevance of mobilizing mesenchymal stromal cells, immune cells, and malignant cells.

Conclusions:

  • Understanding the stem cell niche is key to refining mobilization protocols.
  • Mobilization of diverse cell types has significant clinical implications for transplantation and disease.
  • Further research can enhance HSCT efficacy through optimized mobilization strategies.