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Related Concept Videos

Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...

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Related Experiment Video

Updated: May 29, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

Functional consequences of developmentally regulated alternative splicing.

Auinash Kalsotra1, Thomas A Cooper

  • 1Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.

Nature Reviews. Genetics
|September 17, 2011
PubMed
Summary
This summary is machine-generated.

Alternative splicing generates significant messenger RNA (mRNA) diversity in animals, influencing physiological changes through coordinated regulatory networks. This process impacts various biological functions across species, from basic homeostasis to cell-specific activities.

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Last Updated: May 29, 2026

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Published on: October 9, 2014

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Area of Science:

  • Molecular Biology
  • Genomics
  • Developmental Biology

Background:

  • Genome-wide transcriptome analyses reveal extensive mRNA diversity in metazoans.
  • Alternative splicing is a key mechanism generating this diversity.
  • Regulatory networks controlling splicing orchestrate dynamic transcriptomic remodeling.

Purpose of the Study:

  • To investigate the role of alternative splicing in physiological changes.
  • To understand the regulatory networks governing alternative splicing transitions.
  • To explore the functional classes of genes impacted by alternative splicing.

Main Methods:

  • Genome-wide transcriptome analysis.
  • Identification of regulatory networks controlling alternative splicing.
  • Comparative analysis across different species (yeast, worms, flies, vertebrates).

Main Results:

  • Alternative splicing significantly increases mRNA diversity in metazoans.
  • Coordinated alternative splicing transitions are linked to physiological changes.
  • Splicing regulation affects both homeostatic and cell-type-specific genes.

Conclusions:

  • Alternative splicing plays a critical role in driving physiological change and providing mRNA variability.
  • Understanding splicing regulation is crucial for comprehending diverse biological processes.
  • Splicing contributes to adaptability and functional specialization in multicellular organisms.