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Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles
Rameshwer Shukla1, Elliott Hill, Xiangyang Shi
1Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Abor, MI 48109, USA.
Soft Matter
|September 28, 2011
Abstract:
Monodisperse dendrimer-entrapped gold nanoparticles (diameter = 3.0 nm) were prepared using G5 poly(amidoamine) (PAMAM) dendrimer functionalized with fluorescein isothiocyanate (FI) and Arg-Gly-Asp (RGD) peptide as template; in vitro targeting efficacy to integrin receptor expressing cells was confirmed by flow cytometry, confocal microscopy, and ICP-MS.
