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Updated: May 29, 2026

High Content Screening in Neurodegenerative Diseases
Published on: January 6, 2012
An Image Driven Systems Biology Approach for Neurodegenerative Disease Studies in the TSC-mTOR Pathway
Dominik Beck1, Xiaobo Zhou, Tuan Pham
1Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, Weill Cornell Medical College, Houston, TX, 77030, U.S.A.
Abstract:
In this brief paper we present an overview of the TSC-mTOR pathway and its importance in neurodegenerative disease (ND). We illustrate the influence of ND on dendritic spine morphology. Then we discuss some details of functional gene networks (FGN) and use this information to propose an image driven systems biology approach for the construction of a FGN for ND. We conclude on its importance and the prospective outcome of our study.
