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Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe
Haibin Shi1, Xiamin Cheng, Siu Kwan Sze
1Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Chemical Communications (Cambridge, England)
|September 17, 2011
Abstract:
A clickable, affinity-based probe (AfBP), which was modified from staurosporine (a natural product kinase inhibitor), has been synthesized and used in situ for activity-based proteome profiling of potential cellular targets of staurosporine in HepG2 cancer cells.
