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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
Surgical management of ulcerative colitis
Malika Bennis1, Emmanuel Tiret
1Department of Digestive Surgery, Hôpital Saint-Antoine AP-HP, University Paris VI (Pierre et Marie Curie), 184 rue du Faubourg Saint-Antoine, 75571, Paris Cedex 12, France.
Introduction:
Surgery is the only curative option in the treatment of ulcerative colitis. Despite advances in the medical management surgery is required in about a third of patients.
Surgical Management:
In the acute setting surgery is indicated when medical treatment fails to improve an episode of acute severe colitis. The intervention of choice is a staged colectomy with end ileostomy and preservation of the rectal stump in the first instance. Indications for elective surgery are failure of medical therapy and malignant transformation. The surgical options include conventional proctectomy with ileostomy or a Kock's continent ileostomy and colectomy with an ileorectal anastomosis. The current gold standard is restorative proctocolectomy with ileal pouch-anal anastomosis. Most frequently the technique includes a J pouch with a stapled anastomosis and temporary faecal diversion with a loop ileostomy. Laparoscopic pouch surgery is a feasible and safe option with an excellent cosmetic result.
Conclusions:
Although the morbidity remains significant after surgery, the quality of life is good with a satisfactory long-term functional outcome.
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