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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Adjuvant hormonal therapy in perimenopausal patients
A Pinto Marín1, A I Ballesteros García, Y Izarzugaza Perón
1Oncology Department, Hospital Universitario La Paz, Madrid, Spain.
Advances in Therapy
|September 17, 2011
Summary
Perimenopausal women with breast cancer may receive tamoxifen (TAM) with ovarian suppression. Aromatase inhibitors (AI) are recommended only after confirmed menopause or with chemical castration.
Area of Science:
- Oncology
- Endocrinology
- Gynecology
Background:
- Perimenopause is a transitional phase marked by hormonal fluctuations and irregular menstrual cycles.
- Breast cancer treatment in perimenopausal women requires careful consideration of menopausal status and hormonal therapies.
- Hormonal therapy plays a crucial role in managing hormone-sensitive breast tumors.
Purpose of the Study:
- To review and discuss optimal treatment strategies for perimenopausal women diagnosed with breast cancer.
- To provide guidance on the use of hormonal therapies, including tamoxifen and aromatase inhibitors, in this patient population.
- To highlight key considerations for adjuvant therapy selection based on menopausal status.
Main Methods:
- Review of roundtable presentations and expert discussions on breast cancer hormonal therapy.
- Analysis of treatment guidelines for perimenopausal women with hormone-sensitive breast cancer.
- Evaluation of the role of ovarian suppression and different hormonal agents.
Main Results:
- Tamoxifen (TAM) with or without ovarian ablation is a recommended initial treatment for 2-3 years.
- Aromatase inhibitors (AI) are indicated for postmenopausal women or in combination with chemical castration for premenopausal women.
- Ovarian suppression is a viable adjuvant therapy for hormone-sensitive tumors.
Conclusions:
- Treatment decisions for perimenopausal breast cancer patients hinge on menopausal status and tumor hormone sensitivity.
- Sequential use of TAM followed by AI after confirmed menopause is a common strategy.
- Ovarian suppression can be effectively integrated into adjuvant therapy regimens.
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