Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Macrophages sense and follow physiologically relevant K<sup>+</sup> and Na<sup>+</sup> gradients: how induced dipoles and ionotaxis may explain electrotaxis.

Cell communication and signaling : CCS·2026

Same author

MicroAge mission: experimental design and hardware for a bespoke culture system supporting tissue-engineered skeletal muscle.

NPJ microgravity·2026

Same author

Electrophysiological fingerprints of healthy cervical epithelial and HeLa cells: Membrane potential, zeta potential and passive electrical properties.

PloS one·2025

Same author

Changes in peripheral blood mononuclear cell electrical properties in response to viral exposure and vaccination.

Scientific reports·2025

Same author

Domain-specific AI segmentation of IMPDH2 rod/ring structures in mouse embryonic stem cells.

BMC biology·2025

Same author

Tracking chondrocyte-to-fibroblast transformation via changes in cell electrophysiology.

Scientific reports·2025

Search research articles

Related Experiment Video

Updated: May 29, 2026

Electrotaxis Studies of Lung Cancer Cells using a Multichannel Dual-electric-field Microfluidic Chip

Electrotaxis Studies of Lung Cancer Cells using a Multichannel Dual-electric-field Microfluidic Chip

Published on: December 29, 2015

Real-time cell electrophysiology using a multi-channel dielectrophoretic-dot microelectrode array.

Henry O Fatoyinbo¹, Nahrizul A Kadri, David H Gould

¹Centre for Biomedical Engineering, School of Engineering, University of Surrey, Guildford, UK.

Electrophoresis

|September 17, 2011

Summary

This study introduces a rapid, multi-channel dielectrophoresis (DEP) system for cell biophysical assessment. The new DEP system allows near real-time monitoring of cell electrophysiology, significantly reducing analysis time for drug discovery and diagnostics.

More Related Videos

Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation

Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation

Published on: December 8, 2018

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs)

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs)

Published on: May 12, 2017

Related Experiment Videos

Last Updated: May 29, 2026

Electrotaxis Studies of Lung Cancer Cells using a Multichannel Dual-electric-field Microfluidic Chip

Electrotaxis Studies of Lung Cancer Cells using a Multichannel Dual-electric-field Microfluidic Chip

Published on: December 29, 2015

Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation

Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation

Published on: December 8, 2018

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs)

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs)

Published on: May 12, 2017

Area of Science:

Biophysics
Cellular Electrophysiology

Background:

Dielectrophoresis (DEP) is a valuable technique for analyzing cell electrophysiological properties.
Traditional DEP analysis is time-consuming, limiting its application in rapid, label-free research.

Purpose of the Study:

To develop a programmable, multi-channel DEP system for rapid biophysical assessment of cell populations.
To enable near real-time monitoring of cellular electrophysiological changes.

Main Methods:

Development of a novel assay format with a programmable, multi-channel DEP system.
Simultaneous application of eight AC electrical signals to independently addressable microelectrodes.
Measurement of DEP spectra in 20 seconds with a 90-second cycle time.

Main Results:

Demonstrated rapid DEP spectrum acquisition (20 seconds).
Successfully monitored human leukaemic K562 cells exposed to staurosporine and valinomycin.
Observed early-phase changes in cell membrane properties induced by drugs.

Conclusions:

The developed DEP system significantly accelerates biophysical assessment of cells.
This technology enhances understanding of electrophysiology's role in early drug action.
Enables real-time observation of electrical characteristic changes in cells.