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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: May 29, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

[Peptide vaccination therapy for bone and soft tissue sarcoma].

Makoto Emori1, Tomohide Tsukahara, Satoshi Kawaguchi

  • 1Department of Orthopedic Surgery, Sapporo Medical University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 20, 2011
PubMed
Summary

Peptide vaccination shows safety and immune response in sarcoma patients. Further research is needed to enhance its efficacy against residual tumors, potentially combining it with chemotherapy.

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Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
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Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

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Published on: December 10, 2010

Area of Science:

  • Oncology
  • Immunotherapy

Context:

  • Bone and soft tissue sarcomas, including synovial sarcoma and osteosarcoma, present significant treatment challenges.
  • Current multidisciplinary approaches (surgery, chemotherapy, radiotherapy) often fail to cure metastatic or relapsed disease.

Purpose:

  • To investigate the safety, immunogenicity, and clinical efficacy of peptide vaccination therapy for synovial sarcoma and osteosarcoma.
  • To explore novel therapeutic strategies for refractory sarcoma cases.

Summary:

  • A trial for synovial sarcoma demonstrated that peptide vaccination is safe and elicits an immune response.
  • Partial clinical efficacy was observed, but the vaccine alone was insufficient to control tumors with gross residual disease.
  • Peptide vaccination may be a promising adjuvant therapy when combined with chemotherapy for refractory tumors.

Impact:

  • Highlights the potential of peptide vaccination as a novel therapeutic option for challenging sarcoma cases.
  • Suggests a future direction for treating refractory sarcomas by combining immunotherapy with conventional treatments.
  • Provides preliminary data on the safety and immunogenicity of peptide vaccines in sarcoma patients.