Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cochran's Q Test

Cochran's Q Test

Cochran's Q Test is a nonparametric statistical test used to determine if there are potential differences in the outcomes of three or more related groups on a binary (yes/no) or dichotomous outcome. It is essentially an extension of the McNemar Test, which is limited to two related samples - Cochran's Q test can handle three or more related samples, making it more versatile in scenarios where subjects are measured under multiple conditions. The test statistic follows a Chi-Square distribution,...

Crossover Experiments

Crossover Experiments

Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Clinical Trials: Overview

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

Review and Preview

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Chimeric antigen receptor T cell therapy cardiotoxicity: a narrative review.

Cardio-oncology (London, England)·2026

Same author

Telepharmacy-supported multidisciplinary management and clinical outcomes in patients with transthyretin amyloid cardiomyopathy treated with tafamidis: a real-world study.

Clinical research in cardiology : official journal of the German Cardiac Society·2026

Same author

Advancing beyond multimodality: integrating quantitative imaging biomarkers into the clinical workflow of cardiac amyloidosis. Author's reply.

European journal of internal medicine·2026

Same author

A protocol for the development of a core outcome set for adults with depression.

Journal of clinical epidemiology·2025

Same author

Multimodality imaging for cardiac amyloidosis: clinical applications and future directions.

European journal of internal medicine·2025

Same author

Reducing the Delay in the Diagnosis of Bipolar Disorder: A Qualitative Study.

Health expectations : an international journal of public participation in health care and health policy·2025

Search research articles

Related Experiment Videos

What is a Cochrane review?

A Cipriani¹, T A Furukawa, C Barbui

¹Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy. andrea.cipriani@univr.it

Epidemiology and Psychiatric Sciences

|September 20, 2011

Summary

Cochrane reviews are the gold standard in evidence-based healthcare due to their rigorous methodology. This article details the key methods and editorial processes for Cochrane reviews, ensuring high-quality systematic reviews.

Related Experiment Videos

Area of Science:

Healthcare Research Methodology
Evidence-Based Practice
Systematic Reviews

Background:

Cochrane Collaboration is a globally recognized organization for high-quality systematic reviews.
Their reviews are the benchmark for evidence-based healthcare worldwide.
A common, specific methodology is employed to minimize bias and random error.

Purpose of the Study:

To highlight the essential methodological features of Cochrane reviews.
To provide details on the editorial process for publishing Cochrane reviews.
To underscore the importance of standardized methodology in systematic reviews.

Main Methods:

Focus on the common and specific methodology used in Cochrane reviews.
Description of the systematic review process.
Explanation of bias and random error limitation techniques.

Main Results:

Identification of key methodological elements ensuring review quality.
Overview of the editorial workflow for Cochrane Library publication.
Emphasis on the reproducibility and reliability of Cochrane reviews.

Conclusions:

Cochrane reviews represent the highest standard in evidence-based healthcare.
Adherence to a strict methodology is crucial for minimizing bias and error.
Understanding the editorial process enhances transparency and trust in research findings.