Mayaro fever in the city of Manaus, Brazil, 2007-2008

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Maria Paula Gomes Mourão1, Michele de Souza Bastos, Regina Pinto de Figueiredo

  • 1Fundação de Medicina Tropical Dr. Heitor Viera Dourado (FMT-HVD), Virology Department, Manaus, Amazonas, Brazil. mariapaula.mourao@gmail.com

Vector Borne and Zoonotic Diseases (Larchmont, N.Y.)
|September 20, 2011
PubMed

Insights

Mayaro virus (MAYV) caused acute febrile illness outbreaks in Manaus, Brazil. Researchers detected MAYV antibodies and genome in patients, indicating a significant underreported disease burden.

Area of Science:

  • Arbovirology
  • Infectious Diseases
  • Public Health

Background:

  • Mayaro Alphavirus (MAYV) is an arbovirus responsible for acute febrile illness outbreaks in South America.
  • The Amazon region, particularly the Brazilian Amazon, is endemic for arboviral diseases.

Purpose of the Study:

  • To investigate Mayaro fever cases in Manaus, Amazonas, Brazil, during 2007-2008.
  • To characterize clinical manifestations and confirm Mayaro virus infection in affected individuals.

Main Methods:

  • Sera from 33 patients with suspected Mayaro fever were tested for IgM antibodies against MAYV using enzyme immunoassay.
  • Reverse transcription-polymerase chain reaction (RT-PCR) was employed to detect the MAYV genome in patient blood samples.

Main Results:

  • IgM antibodies to MAYV were detected in 33 patients, aged 6-65 years.
  • The MAYV genome was identified in one of the 33 patients via RT-PCR.
  • Common symptoms included headache, arthralgia, myalgia, ocular pain, and rash.

Conclusions:

  • The study confirms the occurrence of Mayaro fever in Manaus, Brazil.
  • The findings suggest that the reported cases represent a fraction of the actual Mayaro fever burden in the region.
  • Enhanced surveillance and diagnostic efforts are crucial for understanding the epidemiology of MAYV in urban settings.

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