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[The sweat test in cystic fibrosis]
1Interne Kinderabteilung, Wilhelminenspital der Stadt Wien.
Padiatrie Und Padologie
|January 1, 1990
Summary
Cystic Fibrosis patients exhibit high sweat sodium and chloride due to defective ion transport. The Gibson and Cooke sweat test is reliable, with the Wescor Macroduct System offering an easier, though instrument-dependent, alternative.
Area of Science:
- Biochemistry
- Physiology
- Medical Diagnostics
Context:
- Cystic Fibrosis (CF) is a genetic disorder.
- CF affects exocrine glands, leading to abnormal sweat composition.
- Elevated sweat sodium (Na) and chloride (Cl) are key indicators.
Purpose:
- To explain the pathogenetic basis of high sweat Na and Cl in CF.
- To evaluate diagnostic methods for CF sweat testing.
Summary:
- The primary defect in Cystic Fibrosis involves reduced chloride ion (Cl-) transport across exocrine gland cell membranes.
- This defect directly causes the high concentration of Na and Cl observed in CF patient sweat.
- The Gibson and Cooke method is the most reliable sweat test for CF diagnosis.
- The Wescor Macroduct System provides comparable results and is simpler to perform but requires specialized equipment.
Impact:
- Understanding the link between ion transport defects and sweat composition aids CF diagnosis.
- Evaluating different sweat test methods helps optimize diagnostic procedures.
- Improved diagnostic tools can lead to earlier and more accurate CF detection.