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Related Experiment Videos

[Celiac disease (gluten sensitive enteropathy)].

G Granditsch1

  • 1Universitäts-Kinderklinik, Wien.

Padiatrie Und Padologie
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Helicobacter pylori in children and adolescents: increase of primary clarithromycin resistance, 1997-2000.

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[Diagnosis and therapy of celiac disease in adolescence and adulthood].

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IgA cross-reactivity between a nuclear autoantigen and wheat proteins suggests molecular mimicry as a possible pathomechanism in celiac disease.

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Screening by anti-endomysium antibody for celiac disease in diabetic children and adolescents in Austria.

Journal of pediatric gastroenterology and nutrition·2000

Coeliac disease affects 1 in 1000 Austrian births. Diagnosis requires small bowel biopsy to confirm subtotal villous atrophy, not just a gluten-free diet trial.

Area of Science:

  • Gastroenterology
  • Immunology
  • Genetics

Context:

  • Coeliac disease prevalence in Austria is ~1:1000 live births.
  • Diagnosis can be complicated by inappropriate gluten-free diet trials before confirmation.
  • Common symptoms include failure to thrive, deficiency states, and abnormal stools, though often equivocal in relapses and adults.

Purpose:

  • To outline diagnostic criteria and methods for coeliac disease.
  • To emphasize the importance of small bowel biopsy for definitive diagnosis.
  • To discuss the role of serological markers and HLA typing.

Summary:

  • The gold standard for coeliac disease diagnosis is identifying subtotal villous atrophy via small bowel biopsy.
  • Antigliadin and antiendomysial antibodies (IgA and IgG) aid diagnosis, increasing specificity and sensitivity.

Related Experiment Videos

  • Genetic factors (HLA alleles), alongside immunologic and environmental influences, contribute to coeliac disease pathogenesis.

    • Impact:

    • Accurate diagnosis of coeliac disease is crucial for effective management and preventing long-term complications.
    • Understanding diagnostic nuances prevents misdiagnosis and delays in treatment.
    • Highlights the interplay of genetic predisposition, immune response, and environmental triggers in coeliac disease development.