Related Experiment Video

Updated: May 29, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

The Retrospective Cohort of Extended-Infusion Piperacillin-Tazobactam (RECEIPT) study: a multicenter study

Raymond J Yost1, Diane M Cappelletty,

  • 1Department of Pharmacy, Lexington VA Medical Center, Kentucky, USA.

Pharmacotherapy
|September 20, 2011
PubMed
Abstract

Insights

Extended-infusion piperacillin-tazobactam significantly reduced mortality in gram-negative infections compared to standard dosing. This pharmacodynamic approach offers improved survival outcomes for critically ill patients.

Area of Science:

  • Pharmacology and Infectious Diseases
  • Antimicrobial Stewardship

Background:

  • Gram-negative bacterial infections pose a significant threat, necessitating effective antimicrobial strategies.
  • Optimizing antibiotic dosing, such as extended infusions, may improve therapeutic outcomes.
  • Piperacillin-tazobactam is a commonly used broad-spectrum antibiotic for serious infections.

Purpose of the Study:

  • To compare the effectiveness of extended-infusion piperacillin-tazobactam versus standard-infusion beta-lactam antibiotics.
  • To evaluate the impact on mortality and other clinical outcomes in patients with gram-negative infections.

Main Methods:

  • A multicenter, retrospective review of 359 adult patients with gram-negative infections.
  • Patients received either 4-hour extended-infusion piperacillin-tazobactam or nonextended-infusion comparator antibiotics.
  • Data collected included demographics, infection details, and clinical outcomes like mortality and length of stay.

Main Results:

  • In-hospital mortality was significantly lower in the extended-infusion piperacillin-tazobactam group (9.7% vs. 17.9%, p=0.02).
  • Extended-infusion piperacillin-tazobactam was associated with a reduced risk of mortality (OR 0.43, p=0.05).
  • Hospital and ICU length of stay were similar between the groups.

Conclusions:

  • Extended-infusion piperacillin-tazobactam demonstrates favorable outcomes, including reduced mortality, for gram-negative infections.
  • Pharmacodynamic dosing strategies may enhance the efficacy of beta-lactam antibiotics.
  • Further prospective, randomized trials are recommended to confirm these findings.

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