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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Related Experiment Video

Updated: May 29, 2026

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
09:42

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Published on: April 19, 2017

Epigenetics and psoriasis.

P Zhang1, Y Su, Q Lu

  • 1Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, China.

Journal of the European Academy of Dermatology and Venereology : JEADV
|September 20, 2011
PubMed
Summary
This summary is machine-generated.

Epigenetic mechanisms, like DNA methylation and histone modification, are increasingly linked to autoimmune diseases. This review explores their role in psoriasis pathogenesis, suggesting new research directions.

Related Experiment Videos

Last Updated: May 29, 2026

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
09:42

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Published on: April 19, 2017

Area of Science:

  • Immunology
  • Genetics
  • Dermatology

Background:

  • Autoimmune rheumatic diseases like systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) show strong links to epigenetic alterations.
  • The specific pathogenic mechanisms underlying psoriasis, an organ-specific autoimmune disease, are not well understood.
  • Emerging research indicates aberrant epigenetic patterns in psoriasis patients, hinting at their involvement.

Purpose of the Study:

  • To review current epigenetic findings related to psoriasis.
  • To explore the potential role of epigenetic mechanisms in psoriasis pathogenesis.
  • To suggest future research avenues in the epigenetics of psoriasis.

Main Methods:

  • Literature review of recent studies on epigenetics and psoriasis.
  • Analysis of epigenetic alterations in psoriasis patients.
  • Synthesis of findings to understand disease mechanisms.

Main Results:

  • Evidence suggests that epigenetic dysregulation is present in psoriasis.
  • Specific epigenetic modifications may contribute to the development and progression of psoriasis.
  • Further research is needed to elucidate the precise roles of these mechanisms.

Conclusions:

  • Epigenetic mechanisms are likely involved in the pathogenesis of psoriasis.
  • Understanding these epigenetic changes could lead to novel therapeutic strategies for psoriasis.
  • Future studies should focus on identifying specific epigenetic targets and their functional impact in psoriasis.