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Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
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Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Related Experiment Video

Updated: May 29, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Serum proteomic changes in adults with obstructive sleep apnoea.

Bernabe Jurado-Gamez1, Jose Luis Gomez-Chaparro, Maria Muñoz-Calero

  • 1Sleep Unit, Department of Respiratory Medicine, Reina Sofia University Hospital, Cordoba, Spain. bjg01co@hotmail.com

Journal of Sleep Research
|September 20, 2011
PubMed
Summary

Obstructive sleep apnoea (OSA) is associated with altered serum protein levels, particularly involving lipid and vascular pathways. Protein changes vary with OSA severity, offering potential biomarkers for this common sleep disorder.

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Last Updated: May 29, 2026

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Area of Science:

  • Biochemistry
  • Proteomics
  • Sleep Medicine

Background:

  • Obstructive sleep apnoea (OSA) is a prevalent condition with significant health implications.
  • Identifying specific biomarkers for OSA can aid in diagnosis and understanding disease mechanisms.

Purpose of the Study:

  • To investigate differential protein expression in the serum of adult patients with OSA compared to controls.
  • To explore correlations between protein level changes and OSA severity.

Main Methods:

  • Prospective study utilizing isobaric tags for relative and absolute quantification (iTRAQ) techniques.
  • Mass spectrometry analysis (MALDI TOF/TOF) of serum proteins from 10 controls and 30 OSA patients.
  • Subgrouping OSA patients by severity based on apnoea-hypopnoea index (AHI).

Main Results:

  • Identified 103 proteins with differential expression levels between OSA patients and controls.
  • Observed underexpression of C4BPA and thrombospondin in all OSA severity groups.
  • Found varying numbers of overexpressed proteins across mild, moderate, and severe OSA groups, suggesting severity-dependent alterations.
  • Protein alterations were primarily linked to dysregulation in lipid and vascular metabolic pathways.

Conclusions:

  • Differential protein expression is evident in the serum of adults with OSA.
  • Protein expression patterns in OSA are associated with disease severity.
  • The identified protein changes implicate lipid and vascular metabolic pathways in OSA pathogenesis.