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Related Experiment Video

Updated: May 29, 2026

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

[MicroRNA expression profile and pathogenetic initial study in essential hypertension].

Li-Ping Yu¹, Lin-Ying Shi, Ming-Ming Zhang

¹Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Zhonghua Xin Xue Guan Bing Za Zhi

|September 20, 2011

Summary

Essential hypertension patients exhibit distinct microRNA expression profiles. Human cytomegalovirus-encoded microRNA UL112 (hcmv-miR-UL112) was significantly upregulated and may play a role in hypertension development.

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Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

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Last Updated: May 29, 2026

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Area of Science:

Genomics
Molecular Biology
Cardiovascular Research

Context:

Essential hypertension is a complex cardiovascular disease with multifactorial etiology.
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and are implicated in various physiological and pathological processes.
Aberrant miRNA expression has been observed in several diseases, but their role in essential hypertension requires further investigation.

Purpose:

To investigate the differential expression of miRNAs in the plasma of patients with essential hypertension compared to healthy controls.
To identify specific miRNAs that could serve as potential biomarkers for essential hypertension.
To explore the functional targets of differentially expressed miRNAs.

Summary:

MicroRNA profiling of plasma samples from 15 hypertensive patients and 5 healthy controls revealed significant differences in miRNA expression.
A total of 46 miRNAs were differentially expressed, with 27 known miRNAs identified. Among these, 9 were upregulated and 18 were downregulated in hypertensive patients.
Specific miRNAs, including downregulated miR-296-5p and miR-133b, and upregulated let-7e and hcmv-miR-UL112, were validated in an independent cohort. Functional assays indicated that hcmv-miR-UL112 targets MICB and IRF1.

Impact:

The study identifies a distinct miRNA expression signature associated with essential hypertension.
Upregulated hcmv-miR-UL112 suggests a potential role for viral-encoded miRNAs in the pathogenesis of essential hypertension.
These findings may pave the way for novel diagnostic biomarkers and therapeutic strategies for hypertension.