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Chromatin Modification in iPS Cells

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...

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Related Experiment Video

Updated: May 29, 2026

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function

Published on: October 19, 2013

Chromatin modification in zebrafish development.

Jordi Cayuso Mas¹, Emily S Noël, Elke A Ober

¹MRC National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK.

Methods in Cell Biology

|September 20, 2011

Summary

This summary is machine-generated.

Chromatin modifications are crucial for cell differentiation and organism development. This study explores their roles in zebrafish development, regeneration, and gene transcription, highlighting new findings and techniques.

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Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis

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Last Updated: May 29, 2026

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function

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Published on: October 19, 2013

Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis

Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis

Published on: January 12, 2015

Area of Science:

Developmental Biology
Epigenetics
Molecular Biology

Background:

Cellular differentiation relies on diverging transcriptional programs.
Chromatin modifications, including DNA methylation and histone modifications, regulate gene transcription.
These modifications influence genome accessibility, impacting processes like DNA replication and chromosome condensation.

Purpose of the Study:

To describe the roles of chromatin modifications in zebrafish development and regeneration.
To provide an introduction to chromatin modifications and their functions.
To highlight key aspects of their roles in early embryonic development, neural development, digestive system formation, and tissue regeneration.

Main Methods:

Review of recent literature on chromatin modifications in zebrafish.
Description of commonly used techniques for studying chromatin modifications.
Focus on gene transcription and specific developmental processes.

Main Results:

Uncovered roles of chromatin modifications in zebrafish development and regeneration.
Detailed introduction to chromatin modifications and their functions in gene transcription.
Exploration of their significance in early embryogenesis, neural and digestive system development, and tissue regeneration.

Conclusions:

Chromatin modifications are essential regulators of gene transcription during development and regeneration.
Zebrafish serves as a model organism to study these epigenetic mechanisms.
Further research into chromatin modifications can advance understanding of pluripotency, differentiation, and regenerative processes.