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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

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Related Experiment Video

Updated: May 29, 2026

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

[Osteoblast-osteoclast interaction mechanisms].

José A Riancho1, Jesús Delgado-Calle

  • 1Servicio de Medicina Interna, Hospital Universitario Marqués de Valdecilla-IFIMAV, Universidad de Cantabria, Santander, España. rianchoj@unican.es

Reumatologia Clinica
|September 20, 2011
PubMed
Summary

Bone remodeling relies on osteoclasts and osteoblasts. Osteocytes signal these cells, with M-CSF and RANKL being key mediators for bone resorption.

Area of Science:

  • Skeletal Biology
  • Cellular Signaling
  • Bone Metabolism

Context:

  • Bone renewal involves a dynamic balance between bone formation and resorption.
  • Osteocytes, embedded within the bone matrix, act as mechanosensors and orchestrate bone remodeling.
  • The differentiation of osteoclast precursors is a crucial regulatory step in bone resorption.

Purpose:

  • To highlight the role of osteocytes in initiating bone remodeling.
  • To identify key mediators produced by osteoblastic cells that influence osteoclastogenesis.
  • To emphasize the importance of M-CSF and RANKL in bone resorption regulation.

Summary:

  • Osteocytes play a central role in initiating bone remodeling at specific skeletal sites.
  • Osteoblastic cells, including osteocytes, secrete mediators that control osteoclast precursor differentiation.

More Related Videos

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Related Experiment Videos

Last Updated: May 29, 2026

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

  • Macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-B ligand (RANKL) are critical mediators in this process.

    • Impact:

    • Understanding these cellular interactions is vital for developing therapeutic strategies for bone diseases.
    • This research clarifies the signaling pathways governing bone homeostasis.
    • Identifying key mediators like M-CSF and RANKL provides targets for modulating bone resorption and treating conditions like osteoporosis.