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Related Concept Videos

Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...
Decreased pulse rate01:14

Decreased pulse rate

Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with bradycardia...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
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Related Experiment Video

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A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
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Heart rate deceleration runs for postinfarction risk prediction.

Przemyslaw Guzik1, Jaroslaw Piskorski, Petra Barthel

  • 1Department of Cardiology-Intensive Therapy, University of Medical Sciences in Poznan, Poland.

Journal of Electrocardiology
|September 20, 2011
PubMed
Summary
This summary is machine-generated.

A new method for counting heart rate decelerations can identify patients at high risk for mortality after a heart attack. Infrequent deceleration runs on a 24-hour Holter monitor indicate a poor prognosis.

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Published on: July 12, 2022

Area of Science:

  • Cardiology
  • Medical Technology
  • Predictive Analytics

Background:

  • Post-infarction mortality remains a significant clinical concern.
  • Accurate risk stratification is crucial for patient management after myocardial infarction.
  • Beat-to-beat heart rate variability analysis offers potential for risk assessment.

Purpose of the Study:

  • To develop and validate a method for quantifying episodes of uninterrupted beat-to-beat heart rate decelerations.
  • To assess the association between these deceleration runs (DRs) and postinfarction mortality.
  • To establish risk groups based on DR frequency for improved prognostication.

Main Methods:

  • A novel method was developed to count deceleration runs (DRs) from 24-hour Holter recordings.
  • The method was evaluated on large training (1455) and validation (946) cohorts of postinfarction patients.
  • Patients were followed for a median of 24 months to ascertain total, cardiac, and sudden cardiac mortality.

Main Results:

  • Deceleration runs of 2 to 10 cycles were significantly less frequent in non-survivors.
  • A multivariate model using DRs of 2, 4, and 8 cycles identified distinct risk groups.
  • In the training sample, total mortality rates were 1.8% (low-risk), 6.1% (intermediate-risk), and 24% (high-risk), with similar rates in the validation sample.

Conclusions:

  • Infrequent deceleration runs identified by the developed method are indicative of high risk for postinfarction mortality.
  • This method provides a valuable tool for risk stratification in post-myocardial infarction patients.
  • The findings highlight the prognostic significance of heart rate deceleration patterns.