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Updated: May 29, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Reduced microbial attachment by D-amino acid-inhibited AI-2 and EPS production
1Division of Environmental and Water Resources Engineering, School of Civil and Environmental Engineering, Nanyang Technological University, Singapore, Singapore.
Abstract:
This study investigated the effect of D-tyrosine on microbial attachment to hydrophilic glass and hydrophobic polypropylene surfaces. Results showed that D-tyrosine did not influence microbial growth, ATP and substrate utilization, but significantly inhibited the synthesis of autoinducer-2 (AI-2), eDNA and extracellular polysaccharides and proteins, and subsequently reduced microbial attachment onto glass and polypropylene surfaces was observed. It was shown that D-amino acid would be a non-toxic agent for control of microbial attachment.
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