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Published on: July 22, 2022
Analysis of the effectiveness of basic fibroblast growth factor treatment on traumatic perforation of the tympanic
Zhengcai Lou1, Yongmei Tang, Xiaohong Wu
1Department of Otorhinolaryngology, Yiwu Central Hospital, Yiwu, Zhejiang, China. louzhengcai@163.com
Objective:
The aim of this study was to evaluate the effectiveness of basic fibroblast growth factor (bFGF) treatment on traumatic perforation of the tympanic membrane at different time points.
Research Design:
This is a prospective clinical study.
Methods:
Patients with traumatic perforations of the tympanic membrane were given a treatment of gelatin sponge + bFGF at different time intervals of 3 days, 4 to 7 days, 8 to 15 days, and more than 4 weeks after the injury. Healing rate and time of perforation were also observed after 1 month.
Results:
In 147 ears, 144 (98.0%) were healed. The perforation healing rates were 98.6%, 97.6%, 96.3%, and 100%, respectively, at the following time intervals: within 3 days, 4 to 7 days, 8 to 14 days, and 2 to 4 weeks since the injury. This was quite true without any significant difference (P > .05). Meanwhile, in the small perforation healing of 120 ears, the average healing times from admission to perforation within 3 days, 4 to 7 days, and 8 to 14 days after the injury were 7.95 ± 2.07, 6.75 ± 2.67, and 4.18 ± 0.91 days, respectively. No significant difference was found among the 3 groups (P(1) < .01).
Conclusion:
Treating traumatic perforation of the tympanic membrane using the bFGF technique at different times of admissions is quite effective.
