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Related Experiment Video

Updated: May 29, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

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Published on: June 4, 2020

Change in hemostatic intervention after implementation of thromboelastometry.

Anne-Mette Hvas1, Tue Wincentz Boas, Malene Jensen

  • 1Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark. am.hvas@dadlnet.dk

Journal of Cardiothoracic and Vascular Anesthesia
|September 20, 2011
PubMed
Summary

Implementation of thromboelastometry in cardiac surgery reduced recombinant factor VIIa use but did not significantly decrease overall blood product transfusion. Further research is needed to optimize hemostatic interventions.

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Area of Science:

  • Anesthesiology and Critical Care Medicine
  • Transfusion Medicine
  • Surgical Hemostasis

Background:

  • Blood product transfusion and hemostatic interventions are critical in cardiac surgery.
  • Thromboelastometry (TEM) is a point-of-care viscoelastic assay used to guide hemostatic therapy.
  • The impact of TEM implementation on transfusion practices requires ongoing evaluation.

Purpose of the Study:

  • To monitor the utilization of blood products and hemostatic interventions post-TEM implementation.
  • To assess changes in transfusion volumes and the use of specific hemostatic reagents.

Main Methods:

  • Observational prospective study with a historic control group.
  • Comparison of cardiac surgery patients from 2008 (pre-TEM) and 2009 (post-TEM).
  • Analysis of blood product transfusion, recombinant factor VIIa, and fibrinogen usage.

Main Results:

  • Overall blood product use did not significantly decrease; however, red blood cell units decreased in transfused patients (p=0.04).
  • Recombinant factor VIIa use significantly decreased (p=0.04), while fibrinogen use significantly increased (p<0.001).
  • TEM use was associated with higher transfusion of blood products and hemostatic agents (p<0.001).

Conclusions:

  • TEM implementation led to a significant reduction in recombinant factor VIIa usage in cardiac surgery.
  • Overall blood product transfusion rates were not significantly altered by TEM adoption.
  • Increased fibrinogen use and higher transfusion rates in patients undergoing TEM suggest complex hemostatic management adjustments.