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Assessment of skeletal status by quantitative ultrasound at the hand phalanges in children with bronchial asthma--a

Piotr Adamczyk1, Wojciech Pluskiewicz, Zenon Halaba

  • 1Department and Clinic of Pediatrics in Zabrze, Medical University of Silesia, Katowice, Poland. adamczyk@konto.pl

Ultrasound in Medicine & Biology
|September 20, 2011
PubMed

Insights

Asthmatic children using inhaled corticosteroids showed no difference in bone status compared to healthy peers. However, long-term steroid use may slightly impact bone health, warranting caution.

Area of Science:

  • Pediatrics
  • Bone Metabolism
  • Respiratory Medicine

Background:

  • Asthma is a chronic respiratory condition affecting children.
  • Inhaled corticosteroids (ICS) are a primary treatment for pediatric asthma.
  • Concerns exist regarding potential long-term effects of ICS on bone health.

Purpose of the Study:

  • To evaluate the skeletal status of children with asthma treated with ICS.
  • To compare bone status in asthmatic children versus healthy controls using quantitative ultrasound.

Main Methods:

  • Quantitative ultrasound (QUS) measurements were performed on hand phalanges.
  • Sixty-nine asthmatic children and 251 age- and size-matched healthy controls participated.
  • Statistical analysis, including stepwise regression, was used to identify influencing factors.

Main Results:

  • No significant difference in bone status (speed of sound, Z-score) was found between asthmatic children and controls.
  • Cumulative dose of ICS was identified as a potential factor negatively influencing bone status.
  • QUS assessment indicated comparable skeletal status in both groups.

Conclusions:

  • Pediatric asthma patients on ICS do not exhibit altered skeletal status compared to healthy children based on QUS.
  • Long-term corticosteroid therapy requires careful monitoring due to a potential, albeit slight, negative impact on bone health.
  • QUS is a valuable tool for assessing bone status in children with chronic conditions.

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