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[Influenza A H1N1 in neonatal intensive care unit: analysis and lessons]

C Leick-Courtois1, S Haÿs, T Perpoint

  • 1Service de néonatologie, hôpital de La-Croix-Rousse, hospices civils de Lyon, 103, grande rue de La-Croix-Rousse, 69004 Lyon, France. charline.leick@free.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|September 20, 2011
PubMed

Insights

This study highlights the clinical presentation and oseltamivir treatment of H1N1v infection in preterm infants. Oseltamivir was well-tolerated, and PCR and culture methods aided in managing H1N1v containment.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Limited data exists on H1N1v clinical presentation and oseltamivir treatment in preterm infants.
  • The 2009 H1N1v pandemic necessitated understanding its impact on vulnerable infant populations.

Observation:

  • Four infected preterm infants presented with apnea or cough; one required mechanical ventilation.
  • Oseltamivir prophylaxis was administered to 13 contact preterm infants.
  • No digestive intolerance was noted in any of the 17 preterm infants receiving oseltamivir.

Findings:

  • Polymerase chain reaction (PCR) rapidly identified H1N1v infection, aiding initial containment strategies.
  • While PCR remained positive, negative cultures were more indicative of successful H1N1v containment.
  • Infected infants demonstrated the capacity to develop H1N1v immunity post-infection.

Implications:

  • Oseltamivir appears safe and effective for H1N1v treatment and prophylaxis in preterm infants.
  • Differentiated use of PCR and culture is crucial for effective H1N1v management in neonates.
  • Further research into H1N1v in preterm infants is warranted to inform clinical guidelines.

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