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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
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Inflammatory Bowel Disease II: Ulcerative Colitis

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Related Experiment Video

Updated: May 29, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Bullous systemic lupus erythematosus.

Deshan F Sebaratnam1, Dédée F Murrell

  • 1Department of Dermatology, St George Hospital, Gray Street, Sydney, NSW 2217, Australia.

Dermatologic Clinics
|September 20, 2011
PubMed
Summary

Bullous systemic lupus erythematosus (BSLE) is a rare skin condition. It presents unique clinical, histologic, and immunologic features, differing from other blistering diseases.

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Bullous systemic lupus erythematosus (BSLE) is a rare bullous dermatosis occurring in patients with systemic lupus erythematosus.
  • BSLE exhibits clinical and histologic characteristics overlapping with bullous pemphigoid and dermatitis herpetiformis.
  • Immunologically, BSLE is defined by autoimmunity against type VII collagen components, similar to epidermolysis bullosa acquisita.

Purpose of the Study:

  • To delineate the distinct clinical, histologic, and immunologic features of Bullous systemic lupus erythematosus.
  • To provide an updated understanding of the evolving criteria and profiling of BSLE.

Main Methods:

  • Review of clinical presentations of BSLE patients.
  • Histopathologic examination of skin biopsies.
  • Immunofluorescence studies to identify autoantibodies.

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

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Last Updated: May 29, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Main Results:

  • BSLE demonstrates a unique phenotype distinct from other bullous diseases.
  • Autoimmunity to type VII collagen is a key immunologic marker.
  • Heterogeneous immunologic profiles are observed in BSLE patients.

Conclusions:

  • Bullous systemic lupus erythematosus represents a unique bullous disease phenotype.
  • Understanding BSLE's distinct features aids in accurate diagnosis and classification.
  • Further research into BSLE's pathogenesis is warranted.