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Related Concept Videos

Rab Proteins01:14

Rab Proteins

Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
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RNA Structure01:19

RNA Structure

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Overview
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Identification of Footprints of RNA:Protein Complexes via RNA Immunoprecipitation in Tandem Followed by Sequencing (RIPiT-Seq)
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The R2TP complex: discovery and functions.

Yoshito Kakihara1, Walid A Houry

  • 1Department of Biochemistry, University of Totonto, Toronto, Ontario, Canada M5S 1A8.

Biochimica Et Biophysica Acta
|September 20, 2011
PubMed
Summary
This summary is machine-generated.

The R2TP complex, comprising Rvb1, Rvb2, Pih1, and Tah1 proteins, is essential for cellular processes like DNA repair and gene regulation. This review details its discovery and diverse biological functions.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Rvb1 and Rvb2 are AAA+ ATPases crucial for chromatin remodeling, telomere assembly, and snoRNP biogenesis.
  • These ATPases form a functional complex, termed R2TP, with Hsp90 interactors Pih1 and Tah1.
  • The R2TP complex has been identified in both yeast and mammalian cells.

Purpose of the Study:

  • To review the discovery and characterization of the R2TP complex.
  • To discuss the multifaceted roles of R2TP in various cellular pathways.
  • To highlight the emerging importance of R2TP in biological processes.

Main Methods:

  • Literature review of studies on Rvb1, Rvb2, Pih1, and Tah1.
  • Analysis of research identifying the R2TP complex in different organisms.
  • Synthesis of findings on R2TP's involvement in cellular processes.

Main Results:

  • The R2TP complex is conserved across species and essential for box C/D snoRNP biogenesis.
  • R2TP plays critical roles in apoptosis and PIKK signaling pathways.
  • The complex is involved in RNA polymerase II assembly and other cellular functions.

Conclusions:

  • The R2TP complex is a vital molecular machine with diverse regulatory functions.
  • Further research into R2TP mechanisms will illuminate its roles in health and disease.
  • Understanding R2TP's functions is key to comprehending fundamental cellular processes.