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Related Experiment Video

Updated: May 12, 2026

The Aortic Ring Co-culture Assay: A Convenient Tool to Assess the Angiogenic Potential of Mesenchymal Stromal Cells In Vitro

The Aortic Ring Co-culture Assay: A Convenient Tool to Assess the Angiogenic Potential of Mesenchymal Stromal Cells In Vitro

Published on: September 18, 2017

Basic and therapeutic aspects of angiogenesis.

Michael Potente¹, Holger Gerhardt, Peter Carmeliet

¹Vascular Epigenetics Group, Institute for Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University, D-60590 Frankfurt, Germany.

|September 20, 2011

Summary

Understanding how blood vessels grow is key to treating diseases like cancer. New insights into endothelial cell communication offer novel therapeutic strategies for vascular growth disorders.

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Last Updated: May 12, 2026

The Aortic Ring Co-culture Assay: A Convenient Tool to Assess the Angiogenic Potential of Mesenchymal Stromal Cells In Vitro

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Published on: May 31, 2024

Area of Science:

Vascular biology and angiogenesis research.

Background:

Blood vessels are essential for tissue health, but abnormal growth is implicated in diseases like cancer and inflammatory conditions.
Current anti-angiogenic therapies face challenges with efficacy and resistance.
Endothelial cell communication and environmental interactions are critical for vascular network formation.

Purpose of the Study:

To explore emerging principles of vascular growth.
To identify new therapeutic perspectives for vascular diseases.

Main Methods:

Review of recent insights into endothelial cell communication.
Analysis of principles governing vascular network formation.

Main Results:

Established mechanisms of endothelial cell-to-cell and cell-environment communication in vascular development.
Identified emerging principles of vascular network formation.

Conclusions:

New understanding of vascular growth mechanisms offers potential to overcome limitations in current pro- and anti-angiogenic therapies.
Translational research in vascular biology may lead to improved treatments for angiogenesis-related diseases.