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Updated: May 29, 2026
10:44
Influenza A Virus Studies in a Mouse Model of Infection
Published on: September 7, 2017
Insights on influenza pathogenesis from the grave
Jeffery K Taubenberger1, John C Kash
1Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, Room 3E19A.2, MSC 3203, Bethesda, MD 20892-3203, USA. taubenbergerj@niaid.nih.gov
Virus Research
|September 20, 2011
Summary
The 1918 influenza pandemic, causing 50 million deaths, is being studied to prevent future outbreaks. Researchers reconstructed the 1918 virus using genetic sequencing and reverse genetics.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- The 1918-1919 influenza pandemic was the deadliest in history, causing an estimated 50 million deaths globally.
- Understanding the 1918 virus is crucial for preventing future pandemics.
Purpose of the Study:
- To investigate the origin and pathogenicity of the 1918 influenza virus.
- To utilize insights from the 1918 pandemic for future pandemic preparedness.
Main Methods:
- Sequencing of viral RNA fragments from autopsy tissues of 1918 victims.
- Reconstruction of infectious 1918 influenza viruses using reverse genetics.
Main Results:
- Complete genome of the 1918 influenza virus was determined in 2005.
- Infectious viruses with 1918 gene segments were successfully reconstructed.
Conclusions:
- These studies provide significant information on the 1918 virus's origin and pathogenicity.
- Further research is needed to address remaining questions regarding the 1918 influenza virus.
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