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Published on: April 28, 2019
Acute disseminated encephalomyelitis following influenza vaccination
1UBC Hospital, Vancouver, BC, Canada. ashkan.sho@gmail.com
Introduction:
Approximately 5% of cases of acute disseminated encephalomyelitis are preceded by vaccination within 1 month prior to symptom onset. This occurs rarely following influenza immunization.
Methods:
Case presentation and literature review.
Results:
A 75-year-old woman developed acute disseminated encephalomyelitis within 3 weeks of receiving the seasonal influenza vaccine. The patient subsequently passed away, despite treatment with methylprednisolone and plasma exchange therapy.
Conclusions:
The literature on post-influenza vaccination encephalomyelitis is limited. The majority of published cases had favourable outcomes following treatment with intravenous methylprednisolone. Given the limited number of cases, no incidence estimates have been published.
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