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Related Concept Videos

Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Ion Exchange01:17

Ion Exchange

Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or basic...
Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
Detergent Purification of Membrane Proteins01:18

Detergent Purification of Membrane Proteins

Detergents are used to purify the integral proteins of the membrane. The hydrophobic portion of the detergent can replace membrane phospholipids while solubilizing the membrane proteins. When detergent monomers reach a specific concentration in a solution called critical micelle concentration (CMC), they form micelles. Above CMC, the concentration of the detergent monomers remains in equilibrium with the micelle. The number of detergent monomers present in the CMC varies for each detergent, and...
Surface Active Agents01:27

Surface Active Agents

Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...

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Related Experiment Video

Updated: May 29, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

A smart micellar system with an amine-containing polycarbonate shell.

Hua-Fen Wang1, Xiao-Hua Luo, Chen-Wei Liu

  • 1Key Laboratory of Biomedical Polymers, Department of Chemistry, Wuhan University, Wuhan 430072, PR China.

Acta Biomaterialia
|September 20, 2011
PubMed
Summary

Researchers developed novel amphiphilic triblock copolymers, poly(ε-caprolactone)-poly(6,14-dimethyl-1,3,9,11-tetraoxa-6,14-diaza-cyclohexadecane-2,10-dione)-poly(ε-caprolactone) (PCL-PADMC-PCL), for pH-sensitive drug delivery. These PCL-PADMC-PCL micelles show promise as smart drug carriers that respond to pH changes.

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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

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Last Updated: May 29, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles
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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Development of advanced drug delivery systems is crucial for targeted and efficient therapeutic outcomes.
  • pH-responsive materials offer potential for controlled drug release in specific physiological environments.
  • Amphiphilic block copolymers are versatile platforms for self-assembly into nanostructures for drug encapsulation.

Purpose of the Study:

  • To synthesize and characterize amphiphilic triblock copolymers PCL-PADMC-PCL.
  • To investigate the self-assembly of these copolymers into micelles for drug delivery applications.
  • To evaluate the pH-sensitive drug release capabilities of the PCL-PADMC-PCL micelles.

Main Methods:

  • Synthesis of PCL-PADMC-PCL triblock copolymers via ring-opening polymerization using Novozym-435 lipase.
  • Characterization of copolymer structure using Nuclear Magnetic Resonance (NMR) and Differential Scanning Calorimetry (DSC).
  • Micelle formation, characterization (size, morphology via Transmission Electron Microscopy), and critical aggregation concentration determination.
  • Assessment of pH-dependent micellar behavior and drug release studies using prednisone acetate.

Main Results:

  • Successfully synthesized PCL-PADMC-PCL triblock copolymers with controlled block lengths.
  • Confirmed block copolymer structure and absence of cytotoxicity in 293T and HeLa cells.
  • Self-assembled micelles exhibited spherical morphology (30-50 nm diameter) with pH-dependent size variation.
  • Acid-induced micellar swelling observed between pH 6.5 and 4.5, correlating with PADMC block properties.
  • Prednisone acetate-loaded micelles demonstrated acid-induced drug release.

Conclusions:

  • PCL-PADMC-PCL triblock copolymers are biocompatible and form stable micelles.
  • The micelles exhibit significant pH sensitivity, enabling controlled drug release in acidic environments.
  • These PCL-PADMC-PCL micelles show strong potential as smart drug carriers for targeted therapies.