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Progressively bilateral resorption of the mandible
Yi Huang1, Lian Wang, Yuming Wen
1Department of Head and Neck Oncology, West China College of Stomatology, Sichuan University, No. 14, Section 3, Ren Min Nan Road, Chengdu 610041, China.
Summary
This case study presents arrested mandibular resorption, a rare condition potentially linked to Gorham-Stout Syndrome (GSS). Vascular Endothelial Growth Factor (VEGF) is explored as a diagnostic marker for this bone disorder.
Area of Science:
- Medical Case Study
- Pathology
- Oncology
Background:
- Gorham-Stout Syndrome (GSS) is a rare bone disorder characterized by progressive bone loss.
- Research on GSS primarily focuses on bone pathology, often overlooking associated soft tissue changes.
Observation:
- A 32-year-old male patient presented with severe mandibular resorption, with residual bone resembling chopsticks.
- A provisional diagnosis of Gorham-Stout Syndrome (GSS) was made based on clinical presentation and pathological findings.
Findings:
- Vascular Endothelial Growth Factor (VEGF) levels in plasma and tissue fluid were investigated as potential biomarkers for GSS.
- The study highlights a unique case of arrested mandibular resorption with persistent soft tissue pathology, a rarely documented aspect of GSS.
Implications:
- This case suggests VEGF may serve as a diagnostic marker for Gorham-Stout Syndrome.
- Understanding soft tissue involvement in GSS is crucial for comprehensive patient management.
- The arrested resorption in this case offers insights into the potential progression and management of GSS.
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