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Schilder's disease: non-invasive diagnosis and successful treatment with human immunoglobulins
Dror Kraus1, Osnat Konen, Rachel Straussberg
1Pediatrics A, Schneider Children's Medical Center of Israel, 14 Kaplan St., Petah Tiqwa 49202, Israel. drork@clalit.org.il
Abstract:
Schilder's disease (SD) is a rare variant of multiple sclerosis with a predilection to children. It is characterized by focal neurological abnormalities, which are atypical for MS, in conjunction with tumor-like white matter lesions on MRI. We report the case of an 11-year-old girl that demonstrates two important features of the disease: a) the clinical presentation and subsequent course in conjunction with the serial neuroradiological findings stress the feasibility of a non-invasive diagnosis of SD; and b) we report a significant clinical response to treatment with intravenous human Immunoglobulins.
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