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Emergent neutrality in adaptive asexual evolution.

Stephan Schiffels1, Gergely J Szöllosi, Ville Mustonen

  • 1Institut für Theoretische Physik, Universität zu Köln, 50937 Köln, Germany.

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Summary
This summary is machine-generated.

Genetic linkage in nonrecombining genomes creates interference, impacting mutation fixation. This study models adaptive evolution, revealing emergent neutrality that limits adaptation speed and biological function.

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Area of Science:

  • Evolutionary biology
  • Population genetics
  • Genomics

Background:

  • Genetic linkage in nonrecombining genomes influences evolutionary trajectories.
  • Interference interactions between mutations affect their fixation probabilities.
  • Understanding these dynamics is crucial for modeling adaptive evolution.

Purpose of the Study:

  • To develop a comprehensive model of adaptive evolution in linked genomes.
  • To integrate interference interactions between beneficial and deleterious mutations.
  • To predict fixation rates and allele probabilities under linkage.

Main Methods:

  • Developed a unified theoretical framework for linked adaptive evolution.
  • Employed an approximate analytical solution to model interference.
  • Validated predictions with numerical simulations across different environmental scenarios.

Main Results:

  • Interference interactions lead to emergent neutrality for mutations with small selection coefficients.
  • Emergent neutrality results in nearly neutral fixation rates for both beneficial and deleterious alleles.
  • Adaptation speed and the degree of adaptation are significantly limited by interference.

Conclusions:

  • Interference severely compromises biological functions in adapting populations.
  • Linkage and interference impose viability limits on adaptive evolution.
  • The developed model provides a unified framework for understanding these evolutionary constraints.