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Related Experiment Video

Updated: May 29, 2026

Measuring Pressure Volume Loops in the Mouse
09:15

Measuring Pressure Volume Loops in the Mouse

Published on: May 2, 2016

Pressure-volume relation analysis of mouse ventricular function.

Oscar H Cingolani1, David A Kass

  • 1Division of Cardiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

American Journal of Physiology. Heart and Circulatory Physiology
|September 20, 2011
PubMed
Summary
This summary is machine-generated.

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Instantaneous ventricular pressure-volume (P-V) relations offer a comprehensive method for assessing cardiac function. This review summarizes P-V analysis techniques, particularly for mouse models in molecular cardiac physiology research.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Molecular Cardiology

Background:

  • Ventricular pressure-volume (P-V) analysis has been pivotal in understanding cardiac function for nearly 40 years.
  • Initially developed for large mammals and humans, P-V analysis was adapted for rodent models in the late 1990s.
  • This method is now a gold standard for in vivo cardiac function assessment in mice, driving molecular cardiac physiology.

Purpose of the Study:

  • To provide a comprehensive summary of instantaneous ventricular pressure-volume (P-V) analysis.
  • To detail the instrumentation, theory, and calibration methods for P-V analysis in small animal models.
  • To offer insights for researchers focused on genetic and molecular studies of cardiac function.

Main Methods:

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Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect
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Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect

Published on: June 14, 2015

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis
08:05

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis

Published on: May 19, 2021

Related Experiment Videos

Last Updated: May 29, 2026

Measuring Pressure Volume Loops in the Mouse
09:15

Measuring Pressure Volume Loops in the Mouse

Published on: May 2, 2016

Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect
07:38

Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect

Published on: June 14, 2015

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis
08:05

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis

Published on: May 19, 2021

  • Utilizes catheter-based methods for measuring instantaneous ventricular pressure and volume in vivo.
  • Focuses on the calibration of volume signals crucial for accurate P-V loop analysis.
  • Discusses the theoretical underpinnings of P-V analysis for quantifying cardiac function and energetics.

    • Main Results:

    • P-V analysis provides a comprehensive assessment of ventricular chamber function, energetics, and cardiovascular interactions.
    • The catheter-based approach is the most widely adopted method for P-V analysis in mice.
    • This technique facilitates detailed examination of cardiac function in genetically modified mouse models.

    Conclusions:

    • Instantaneous ventricular P-V analysis is an indispensable tool for modern cardiac research, especially in mice.
    • The review aims to simplify the application and interpretation of P-V analysis for non-engineering specialists.
    • P-V analysis continues to be a cornerstone for advancing molecular cardiac physiology and understanding cardiovascular diseases.