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Related Concept Videos

Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Microtubules in Signaling01:22

Microtubules in Signaling

The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
Studying the Cytoskeleton01:17

Studying the Cytoskeleton

The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.

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Related Experiment Video

Updated: May 29, 2026

Artificial Intelligence Approaches to Assessing Primary Cilia
08:58

Artificial Intelligence Approaches to Assessing Primary Cilia

Published on: May 1, 2021

Cilia and models for studying structure and function.

Lawrence E Ostrowski1, Susan K Dutcher, Cecilia W Lo

  • 1Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. ostro@med.unc.edu

Proceedings of the American Thoracic Society
|September 20, 2011
PubMed
Summary
This summary is machine-generated.

Researchers utilize diverse model systems like Chlamydomonas, human cilia, and mouse models to study ciliary axoneme structure and function, aiding ciliopathy understanding and treatment.

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Last Updated: May 29, 2026

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Published on: August 8, 2013

Area of Science:

  • Cell Biology
  • Genetics
  • Biochemistry

Background:

  • Cilia are crucial cellular organelles with a conserved axoneme structure.
  • Ciliopathies are a group of genetic disorders caused by ciliary dysfunction.
  • Understanding cilia structure and function is vital for treating these diseases.

Purpose of the Study:

  • To review the overlap between primary and motile cilia structure.
  • To present advancements in understanding cilia structure and function.
  • To discuss potential therapeutic approaches for ciliopathies.

Main Methods:

  • Comparative analysis of Chlamydomonas, human cilia, and mouse models.
  • Review of existing literature on cilia structure and function.
  • Exploration of genetic manipulation and physiological studies.

Main Results:

  • Each model system offers unique advantages for studying cilia.
  • Chlamydomonas excels in motility and axoneme component studies.
  • Human cilia provide direct tissue relevance, while mouse models offer insights into disease pathology.

Conclusions:

  • Diverse model systems are essential for comprehensive cilia research.
  • Knowledge gained from model systems can inform therapeutic strategies for ciliopathies.
  • Further research integrating findings from multiple models will advance ciliopathy treatment.