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Updated: May 29, 2026

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
Microsporidial stromal keratitis successfully treated with medical therapy: a case report
Vishram A Sangit1, Somasheila I Murthy, Prashant Garg
1Cornea and Anterior Segment Services, L.V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India.
Purpose:
To report a case of stromal microsporidiosis that responded to medical treatment with systemic albendazole and topical chlorhexidine.
Methods:
A 14-year-old adolescent girl presented with a 3-month history of recurrent redness, pain, and dense anterior stromal corneal infiltrate. Repeated microbiological evaluation helped identify microsporidia from the fifth scraping. Initial therapy with fluoroquinolones failed; 0.02% topical chlorhexidine gluconate hourly and 400 mg of oral albendazole twice daily and later 0.5% loteprednol etabonate were given for a total of 12 weeks.
Results:
There was complete resolution of the infection with corneal scarring with no episodes of recurrence at 1 year of follow-up. The final best-corrected visual acuity was 20/30.
Conclusions:
The diagnosis of microsporidia can be challenging, and corneal scraping should be repeated several times in cases having a high index of suspicion. Medical therapy can prove successful in selected cases where the infection may be limited to midstroma.
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