Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stress-induced cortisol release in hypothalamic hypoadrenalism.

A R Glass, C E Smith

    JAMA
    |April 13, 1979
    PubMed
    Summary

    Hypoadrenalism can occur after hypothalamic treatment. However, stress-induced cortisol release may remain intact despite abnormal diurnal and feedback regulation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Centrality dependence of charged-hadron transverse-momentum spectra in d+Au collisions at sqrt[s(NN)]=200 GeV.

    Physical review letters·2003
    Same author

    Effects of fluoride on rat dental enamel matrix proteinases.

    Archives of oral biology·2002
    Same author

    National health expenditures, 1999.

    Health care financing review·2002
    Same author

    Journal writing as a complementary therapy for reactive depression: a rehabilitation teaching program.

    Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses·2002
    Same author

    Family Caregivers' Motives for Helping Scale derived from motivation-to-help theory.

    Journal of nursing measurement·2002
    Same author

    Development of the blood-nerve barrier in neonatal rats.

    Microsurgery·2002

    Area of Science:

    • Endocrinology
    • Neuroendocrinology
    • Oncology

    Background:

    • Craniopharyngioma treatment, including surgery and radiotherapy, can lead to hypopituitarism and secondary hypoadrenalism.
    • Hypoadrenalism is characterized by insufficient production of cortisol by the adrenal glands, often due to dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis.

    Observation:

    • A 52-year-old woman presented with hypoadrenalism following treatment for craniopharyngioma.
    • She exhibited low 8 AM plasma cortisol, suppressed adrenocorticotropic hormone (ACTH) levels, absent diurnal cortisol variation, and a blunted response to metyrapone.
    • Paradoxically, normal plasma cortisol responses were observed following insulin-induced hypoglycemia and administration of vasopressin or synthetic ACTH.

    Findings:

    • The patient's hormonal profile indicated significant dysfunction in the HPA axis's diurnal and feedback regulatory mechanisms.
    • Despite these regulatory deficits, the adrenal cortex demonstrated a preserved capacity for cortisol release in response to acute stress stimuli.
    • This suggests a dissociation between basal/regulated cortisol secretion and stress-induced responsiveness.

    Implications:

    • Stress-induced cortisol release may be preserved even when diurnal and feedback regulation of the HPA axis is compromised.
    • Understanding these dissociations is crucial for managing patients with hypoadrenalism post-neurosurgical or radiation treatment.
    • Further research into the differential regulation of cortisol secretion can inform clinical monitoring and therapeutic strategies.

    Related Experiment Videos