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Updated: May 29, 2026

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
Published on: May 12, 2023
Unintentional fatal phosphine gas poisoning of a family
Tara J Lemoine1, Kristin Schoolman, Geoffrey Jackman
1Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA. Don.vernon@hsc.utah.edu
Objective:
The objective of the study was to report the toxicity of phosphine gas after a residential fumigation that resulted in fatal poisoning of a 15-month-old toddler and her 4-year-old sibling.
Methods:
This is a case report and a review of literature.
Results:
A family of 6 members was exposed to phosphine gas after their yard was treated with aluminum phosphide for a rodent infestation. The inhalation of phosphine gas initially caused symptoms of abdominal distress in all of the family members. Within 36 hours of exposure, the 4-year-old sibling died of cardiopulmonary failure in a local emergency department. After an initial presentation of respiratory distress, the 15-month-old toddler progressed to complete cardiopulmonary collapse and did not survive despite aggressive intervention including extracorporeal membrane life support.
Conclusions:
Unintentional phosphine gas exposure is rare but has a toxic profile that results in a high fatality rate with no known antidote.
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