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Related Concept Videos

Blind Procedures02:07

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
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Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

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Related Experiment Video

Updated: May 29, 2026

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
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Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

Published on: October 7, 2017

Mild procedure: single-site prospective IRB study.

Sanghamitra Basu1

  • 1Lab2Marche, LLC, North Durango Drive, Las Vegas, NV 89149, USA. research@lab2marche.com

The Clinical Journal of Pain
|September 20, 2011
PubMed
Summary
This summary is machine-generated.

The mild lumbar decompression procedure offers a safe and effective treatment for lumbar spinal stenosis (LSS). Patients experienced significant improvements in pain and function after this minimally invasive therapy.

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Area of Science:

  • Minimally Invasive Spine Surgery
  • Interventional Pain Management
  • Neurosurgery

Background:

  • Symptomatic lumbar spinal stenosis (LSS) significantly impacts quality of life.
  • Conservative therapies and open surgery present limitations for LSS patients.
  • The mild procedure offers an early, minimally invasive alternative for LSS.

Purpose of the Study:

  • To evaluate the 6-month safety and efficacy of the mild lumbar decompression procedure.
  • To assess patient outcomes following the mild procedure for LSS.
  • To determine the effectiveness of mild as an alternative to surgery for LSS.

Main Methods:

  • Prospective study of 27 consecutive LSS patients treated with the mild procedure.
  • Efficacy assessed using Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and Zurich Claudication Questionnaire (ZCQ).
  • Safety monitored for device or procedure-related adverse events and postoperative observation time.

Main Results:

  • No significant adverse events related to the mild procedure were reported.
  • Statistically significant improvements observed in VAS (5.2 points) and ODI (24.0 points) at 6 months.
  • All Zurich Claudication Questionnaire domains showed significant improvement, with high patient satisfaction.

Conclusions:

  • The mild procedure demonstrates a remarkable safety profile for LSS patients.
  • Significant improvements in quality of life and functional outcomes were observed at 6 months.
  • Mild is a safe, effective, and potentially cost-effective treatment option for LSS patients who failed conservative therapy.