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Depressive disorders in schizophrenia
1Professor & Head, Dept. of Psychiatry, Kasturba Medical College Hospital, Manipal - 576 119, Karnataka.
Indian Journal of Psychiatry
|September 20, 2011
Summary
Depression in schizophrenia may be intrinsic or emerge after neuroleptic treatment. While some patients improve, others develop depression during treatment, suggesting neuroleptics might contribute to depressive disorders in schizophrenia.
Area of Science:
- Psychiatry
- Clinical Psychology
Background:
- Depressive mood disorders are a significant concern in schizophrenia.
- Understanding the temporal relationship between schizophrenia, depression, and neuroleptic treatment is crucial for patient care.
Purpose of the Study:
- To investigate the prevalence and course of depressive disorders in schizophrenia patients.
- To examine the impact of neuroleptic treatment on depressive symptoms over time.
Main Methods:
- A longitudinal study of 146 schizophrenia patients meeting Research Diagnostic Criteria.
- Regular follow-up for at least 6 months, assessing depressive symptoms at illness onset and after 8 weeks of neuroleptic treatment.
Main Results:
- No significant difference in overall depression rates at illness onset (49 cases) versus final follow-up (56 cases).
- Following 8 weeks of neuroleptic treatment, 47% of depressed patients showed symptom resolution.
- Conversely, 53% of patients with depression at follow-up had no prior depressive symptoms, indicating onset post-treatment.
Conclusions:
- Depression appears to be an intrinsic feature of schizophrenia.
- Neuroleptic treatment may play a role in the causation or exacerbation of depressive disorders in some schizophrenia patients.
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