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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Renal function after long term treatment with lithium.

M K Dhar1, M S Bhatia, P Agrawal

  • 1Senior Resident, Department of Psychiatry, Lady Hardinge Medical College and associated Smt. Sucheta Kriplani Hospital, New Delhi - 1.

Indian Journal of Psychiatry
|September 20, 2011
PubMed
Summary
This summary is machine-generated.

Long-term lithium prophylaxis for manic depressive psychosis can affect kidney function. Regular renal assessments are crucial even with normal serum lithium levels to prevent progressive impairment.

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Area of Science:

  • Nephrology
  • Psychiatry
  • Pharmacology

Background:

  • Lithium is a common treatment for manic depressive psychosis.
  • Long-term lithium use may impact renal function.
  • Monitoring kidney health is essential for patients on lithium therapy.

Purpose of the Study:

  • To evaluate renal functions in patients with manic depressive psychosis on long-term lithium prophylaxis.
  • To compare renal function between lithium-treated patients and those on other psychotropic drugs.

Main Methods:

  • Studied 30 patients on lithium prophylaxis and 15 controls on other psychotropic drugs.
  • Assessed urine output, urinary osmolality after fluid deprivation, and creatinine clearance.
  • Analyzed the ratio of urinary and serum creatinine and uric acid excretion.

Main Results:

  • Some patients on lithium showed increased urine output and impaired urinary osmolality.
  • Three patients had creatinine clearance below 70 ml/min.
  • Lithium group had significantly lower urinary/serum creatinine ratio and increased uric acid excretion.

Conclusions:

  • Long-term lithium therapy, even within normal serum levels, is associated with altered renal function markers.
  • Regular renal function monitoring is recommended for patients on lithium prophylaxis to detect and prevent potential kidney damage.