A comparative study of dothiepin (prothiaden) and imipramine in depression

In a single-blind, randomised, parallel-group study comparing the efficacy and tolerability of dothiepin (50-150 mg per day) and imipramine (50-150 mg per day) for 6 weeks, involving 60 adult patients with depression, it was observed that dothiepin was comparable to imipramine in terms of efficacy as assessed by Hamilton Rating Scale for depress ion, global scale for severty of illness and clinician's overall assessment of efficacy. Dothiepin was found to have a significantly earlier onset of anxiolytic action compared to imipramine. Dothiepin was well tolerated.