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Updated: May 29, 2026

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
Published on: August 2, 2021
Initial response to ect as a predictor of outcome in endogenous depression
C Andrade1, B N Gangadhar, M Vythilingam
1Lecturer, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029.
Abstract:
In a double-blind, prospective study, 29 patients with endogenous depression were treated with electroconvulsive therapy (ECT). The degree of attenuation in Hamilton Rating Scale for Depression scores after the first ECT was compared between ECT responders and non-responders at the end of the treatment course; a significant difference was obtained, indicating higher initial response in ECT responders. It is therefore suggested that response to a single trial ECT may form the basis for prediction of response of endogenous depression to a course of ECT. An operationalization of this concept is proposed, its sensitivity and specificity calculated, and its implications discussed.
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