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Updated: May 29, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

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Published on: June 12, 2021

Cardiogenic shock with imipramine.

S Chaudhury¹, M Augustine

¹Psychiatrist, 151 Base Hospital, C/o 99 APO.

Indian Journal of Psychiatry

|September 20, 2011

Summary

A patient developed cardiogenic shock, a rare side effect of imipramine treatment for depression. This serious condition was successfully managed with inotropic support, highlighting antidepressant risks.

Area of Science:

Cardiology
Psychopharmacology
Internal Medicine

Background:

Tricyclic antidepressants (TCAs) like imipramine are commonly used for depression.
While effective, TCAs carry potential cardiovascular risks.
Cardiogenic shock is a rare but severe adverse effect associated with TCA use.

Purpose of the Study:

To report a case of cardiogenic shock in a patient treated with imipramine.
To emphasize the importance of recognizing rare adverse effects of antidepressants.
To discuss the successful management of TCA-induced cardiogenic shock.

Main Methods:

Case report of a 35-year-old physically healthy individual.
Patient was undergoing treatment for depression with imipramine and electroplexy.

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Cardiogenic shock was diagnosed and managed.

Main Results:

The patient developed cardiogenic shock during treatment with imipramine.
Cardiogenic shock was successfully managed using inotropic support.
This highlights a rare and potentially fatal side effect of tricyclic antidepressants.

Conclusions:

Cardiogenic shock is a critical, albeit rare, adverse event linked to imipramine.
Prompt recognition and management with inotropic support are crucial for patient survival.
Clinicians should be vigilant for severe cardiovascular complications in patients on TCAs.