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Clomipramine induced mania.
V Sathyanarayana1, S Khanna, S M Channabasavanna
1Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore.
Indian Journal of Psychiatry
|September 20, 2011
Summary
A patient with Obsessive Compulsive Disorder developed delusional mania during clomipramine treatment. Symptoms resolved upon drug cessation, suggesting a potential link between serotonin and manic episodes.
Area of Science:
- Psychiatry
- Neuroscience
- Pharmacology
Background:
- Obsessive Compulsive Disorder (OCD) is a chronic mental health condition.
- Selective serotonin reuptake inhibitors (SSRIs) like clomipramine are common OCD treatments.
- Serotonin's role in mood regulation is complex and not fully understood.
Purpose of the Study:
- To present a case of drug-induced mania.
- To explore the potential link between clomipramine, serotonin, and manic symptoms.
- To highlight the importance of monitoring for mania in patients on clomipramine.
Main Methods:
- Case report presentation.
- Clinical observation of patient's symptoms and response to medication.
- Literature review on serotonin and mania.
Main Results:
- A patient with no prior psychiatric history developed delusional mania while treated with clomipramine.
- Manic symptoms completely resolved after discontinuing clomipramine.
- The case suggests a possible association between clomipramine and the onset of mania.
Conclusions:
- Clomipramine treatment may precipitate manic episodes in susceptible individuals.
- Further investigation into the serotonergic mechanisms underlying mania is warranted.
- Clinicians should be vigilant for manic symptoms in patients undergoing clomipramine therapy for OCD.
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