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Cow's Milk Allergy among Children with Gastroesophageal Reflux Disease

Fatemeh Farahmand1, Mehri Najafi, Pedram Ataee

  • 1Division of Pediatric Gastroenterology, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Gut and Liver
|September 20, 2011
PubMed

Insights

Cow's milk allergy (CMA) is frequently observed in infants with gastroesophageal reflux disease (GERD). Eliminating cow's milk resolved symptoms in one-third of GERD patients, suggesting CMA mimics or worsens GERD.

Area of Science:

  • Pediatric Gastroenterology
  • Allergy Immunology

Background:

  • Gastroesophageal reflux disease (GERD) and cow's milk allergy (CMA) are prevalent infant conditions.
  • Investigating the overlap between GERD and CMA is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To determine the frequency of CMA in infants diagnosed with GERD.
  • To assess the impact of cow's milk elimination on GERD symptoms.

Main Methods:

  • Eighty-one infants with GERD symptoms were evaluated.
  • Initial treatment involved omeprazole; non-responders underwent dietary cow's milk elimination.
  • Symptom resolution was monitored over 4 weeks.

Main Results:

  • Two-thirds (66.7%) of infants responded to omeprazole.
  • In the remaining 27 infants, eliminating cow's milk resolved all GERD signs and symptoms.
  • Gastrointestinal symptoms were most common (72/81), followed by respiratory complaints (9/81).

Conclusions:

  • Cow's milk allergy (CMA) was identified in approximately one-third of pediatric GERD cases.
  • CMA can present as, or exacerbate, severe GERD symptoms in infants.
  • Dietary assessment for CMA is recommended for infants with persistent or severe GERD.
Abstract

Keywords:
Cow's milk allergyFood hypersensitivityGastroesophageal reflux disease

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