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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

Association between Helicobacter pylori Seropositivity and the Coronary Artery Calcium Score in a Screening

Min Jung Park1, Seung Ho Choi, Donghee Kim

  • 1Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.

Gut and Liver
|September 20, 2011
PubMed

Insights

Helicobacter pylori infection is linked to coronary artery calcification (CAC) presence, especially in early stages. This suggests H. pylori seropositivity may indicate a higher risk for coronary atherosclerosis, independent of other risk factors.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Radiology

Background:

  • Helicobacter pylori is associated with extragastric conditions, including coronary heart disease.
  • Coronary artery calcification (CAC) scoring via CT is a screening tool for coronary atherosclerosis.

Purpose of the Study:

  • To investigate the association between H. pylori seropositivity and CAC scores in a general screening population.
  • To determine if H. pylori infection is an independent risk factor for coronary atherosclerosis.

Main Methods:

  • A cohort of 2,029 asymptomatic individuals undergoing health checkups were enrolled.
  • CAC scores were determined using multidetector CT scans.
  • H. pylori seropositivity was assessed via antibody immunoglobulin G testing; traditional cardiovascular risk factors were evaluated.

Main Results:

  • 59.8% of subjects were H. pylori positive; no significant baseline differences were observed between seropositive and seronegative groups.
  • Multivariate analysis showed H. pylori seropositivity was significantly associated with the presence of CAC.
  • The association between H. pylori and CAC was stronger in the mild CAC score category, indicating early atherosclerosis.

Conclusions:

  • H. pylori seropositivity is linked to an increased risk of coronary atherosclerosis.
  • This association persists even after accounting for traditional cardiovascular risk factors.
  • H. pylori infection may be a significant indicator of early coronary atherosclerosis.
Abstract

Keywords:
Coronary atherosclerosisHelicobacter pyloriScreeningSeropositivity

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