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Updated: May 29, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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Published on: December 2, 2015

Is depression an inflammatory disorder?

Charles L Raison1, Andrew H Miller

  • 1Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365C Clifton Road, Fifth Floor, Atlanta, GA 30322, USA. craison@emory.edu

Current Psychiatry Reports
|September 20, 2011
PubMed
Summary
This summary is machine-generated.

Major depressive disorder (MDD) may be linked to inflammation, but evidence suggests this inflammatory connection impacts only a subset of patients. The extent of impact varies based on individual vulnerability and interconnected physiological systems.

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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

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Published on: December 2, 2015

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Area of Science:

  • Neuroscience
  • Immunology
  • Psychiatry

Background:

  • Major depressive disorder (MDD) is frequently associated with elevated peripheral inflammatory biomarkers compared to non-depressed individuals.
  • This correlation often leads to the interpretation that MDD itself may be an inflammatory condition, even in medically healthy patients.

Purpose of the Study:

  • To critically examine the evidence supporting and refuting the hypothesis that MDD is an inflammatory condition.
  • To explore the nuanced relationship between MDD, the immune system, and inflammation.

Main Methods:

  • Review and analysis of existing scientific literature on inflammatory biomarkers in MDD.
  • Examination of patterns in inflammatory findings to understand their implications for MDD etiology.

Main Results:

  • Data suggest inflammation contributes to depression in a specific subset of patients.
  • The influence of inflammatory activation on depression may be widespread but varies with individual vulnerability.

Conclusions:

  • The role of inflammation in MDD is complex and likely patient-specific.
  • Understanding these variations is crucial for developing targeted therapeutic strategies for depression.